C-peptide: a redundant relative of insulin?
نویسندگان
چکیده
منابع مشابه
study of comparative effects of harmine and ghrelin agonist on insulin and c-peptide secretion
Aim and Background: The ability to secrete insulin from the islets of Langerhans on the one hand and suppress the factors that increase serum glucose concentrations on the other; It is very important in patients with metabolic disorders such as diabetes. The aim of this study was to compare the effects of harmine with ghrelin agonist (as a suppressor of insulin secretion) on insulin secretion a...
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OBJECTIVE Glucose-stimulated islet insulin or C-peptide secretion experiments are a fundamental tool for studying and assessing islet function. The goal of this work was to develop Ab-based fluorescent homogenous sensors that would allow rapid, inexpensive, near-instantaneous determinations of insulin and C-peptide levels in biological samples. RESEARCH DESIGN AND METHODS Our approach was to ...
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The renal extraction and excretion of bovine proinsulin, insulin, and C-peptide and the contribution of the kidney to their total metabolic clearance rate (MCR) were studied in the rat. Metabolic clearance rates were measured by the constant infusion technique and plasma and urine concentrations of each polypeptide were determined by radioimmunoassay. The MCR of insulin (16.4+/-0.4 ml/min) was ...
متن کاملUnraveling the aggregation propensity of human insulin C-peptide.
Over the last 20 years, proinsulin C-peptide emerged as an important player in various biological events. Much time and effort has been spent in exploring all functional features of C-peptide and recording its implications in Diabetes mellitus. Only a few studies, though, have addressed C-peptide oligomerization and link this procedure with Diabetes. The aim of our work was to examine the aggre...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2007
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-006-0576-x